Master of Pharmaceutical Biotechnology

Mission

To found the knowledge and skills of pharmaceutical biotechnology among pharmacists for quality and evidence based drugs and vaccines production.

Vision

To graduate high-level expertise in identifying, characterizing and manufacturing biopharmaceutical products.

Admission

July of each year.

Admission Requirments

  • This follows the Admission requirements set by the School of Graduate Studies and approved by the University Academic
  • Specific requirement is the applicant should hold an honour Bachelor Degree from AUW or an equivalent degree from another recognized institution in

Degree requirements

Courses       33 
Thesis    9

 

Curriculum Outline

 

Semester One

Course code      Course Title

 

Credits

PHRM 701     Introduction to Pharmaceutical Biotechnology

3

PHRM 702     Cell biology/Human Cytogenetic /Cell culture

2

PHRM 703     Microbiology

2

PHRM 704     Genomics

1

PHRM 705     Proteomics/ Enzyme kinetics

2

PHRM 706     Drug Delivery

1

 

Semester Two

Course code      Course Title

 

Credits

PHRM 707     Control of Bioreactor Cultivations

1

PHRM 708     Regulatory Aspects

2

PHRM 709     Economical and Marketing Aspects: Patents and Licensing.

1

PHRM 710     Downstream processing

2

PHRM 711     Bioinformatics for structure analysis.

2

PHRM 712     Drug Design

3

PHRM 713     Pharmacology of Biotech Agents

1

 

Semester Four

Course code     Course Title         Credits

PHRM 799          Thesis                    9

 

Course Descriptions

PHRM 701             Introduction  to Pharmaceutical Biotechnology                                              3 cr.

The course covers the concepts and operating processes related to the design, production, control and employment of biotechnology products for therapy, diagnosis and cosmetics. The course delivers up-to-date subject matter on multiple protein expression systems for production of diverse biopharmaceuticals, encompassing a range of platform technologies.

PHRM 702             Cell  biology/Human  Cytogenetic /Cell culture                                               3 cr.

The course describes human cytogenetic, the link between chromosomal defects and diseases and advances in cytogenetic technology. As a mature enterprise, cytogenetic course informs human genomics, disease and cancer genetics, chromosome evolution and the relationship of nuclear structure to function.

PHRM 703             Microbiology                                                                                                    2 cr.

The course covers the infectious diseases that are of great or potential importance to humans. It emphasizes on endemic bacteria, viral and fungal infectious diseases and their impact upon health.

PHRM 704             Genomics                                                                                                         1 cr.

The course covers the traditional areas of genome sequencing and protein sequence and structure analysis, beside the computational and statistical skills necessary to deal with high- throughput measurements of gene expression (microarrays) and the proteome.

PHRM 705             Proteomics/ Enzyme Kinetics                                                                          2 cr.

The course presents the fundamental concepts of proteomics. Proteomics seeks to identify and to characterize all the proteins synthesized in a cell or a tissue and how individual proteins or protein collectives function. Methodology used to analyze and identify proteins and their application in pharmaceutical biotechnology through studying enzymes kinetics will be covered.

PHRM 706             Drug Delivery                                                                                                   1 cr.

This course introduces students to the concept of drug delivery systems that provide pharmaceutical agents at target tissues, the mechanism of pharmacokinetic regulation, the basics, technology, and applications of drug delivery systems. The emphasis is on understanding the principles of pharmacokinetics and drug delivery systems to improve clinical efficacy as well as to reduce side effects and on realizing the importance of the field, drug delivery.

PHRM 707             Control  of Bioreactor Cultivations                                                                   1 cr.

This course theoretical studies are complemented by hands-on experience of fully controlled fermenters that are up to pilot-plant scale and are linked to modern monitoring and control systems. In-depth studies include microbial physiology and fermentation technology; topics in biotechnology; industrial bioprocesses; microbial production of novel metabolites; bioactive compounds; types of bioreactors; monitoring and control of fermentation; and design of bioprocesses with a strong industrial bias.

PHRM 708             Regulatory Aspects                                                                                           2 cr.

The course describes and demonstrates the quality procedure and different quality aspects to please the costumer. It also explains the quality of solid and parenteral dosage forms, the quality of water used in production and air conditioning in pharmaceutical technology.

PHRM 709             Economical and Marketing Aspects: Patents and Licensing                          1 cr.

The course provides an overview of the regulations, discussion of the FDA’s advertising oversight, and FDA enforcement activities. The course content introduces students to advertising approved products. It provides insights on comparing competitor products and the need for head-to-head comparative data, dietary supplements, Rx products, OTC products, unapproved investigational products, and unapproved research products.

PHRM 710              Downstream Processing                                                                                   2 cr.

The course describes the foundation for new and improved processes and products in today’s biochemical process industry. The production of therapeutic proteins and how biotechnology has led to marked improvement and expansion in the traditional biochemical process industry for production of enzymes, diagnostics, chemicals, pharmaceuticals, and foods and how continued introduction of new technology necessitates innovation in process development scale-up and design. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification.

PHRM 711             Bioinformatics  for Structural Analysis                                                             2 cr.

The course covers the fundamental concepts and methods in bioinformatics. It surveys a wide range of topics including computational sequence analysis, sequence homology searching and motif finding, gene finding and genome annotation, protein structure analysis and modeling, genomics and SNP analysis, DNA microarrays and gene expression analysis, Proteomics, network/systems biology, and biological knowledge discovery.

PHRM 712              Drug Design                                                                                                      3 cr.

It is an advanced course in Protein modeling and drug design. It will provide a systematic introduction to the major techniques, algorithms and tools used in Protein Bioinformatics. The students are expected to learn some computational tools at the beginning of the course and utilize these techniques in various bioinformatics assignments.

PHRM713              Pharmacology  of Biotech Agents                                                                    1 cr.

The course is designed to provide students with basic and advanced knowledge of pharmacogenomics, gene therapy and pharmacology of biotech agents.

PHRM 720             Formulation  of Therapeutic Proteins                                                              1 cr.

The course describes the current peptide protein drug which are physiological peptides i.e. insulin, clotting factor and therapeutic peptides i.e. antibodies infliximab (IgG) and urokinase and non-physiological peptides vaccine with emphasis on main chemotherapy area, hormones, hematology and cancer therapy.

PHRM 721             Immunology and Immunotherapy                                                                    2 cr.

The course the concepts related to the following topics: basic concepts in immunology, components of the immune system, principles of innate and adaptive immunity, antigen recognition. Development, maturation and survival of lymphocytes, adaptive immunity to infection, failures of host defense mechanisms, passive, adoptive and active immunotherapy of human diseases. Both antibody and vaccine cancer therapies and the immunology of the tumor host interface will be covered.

PHRM 722             Gene Therapy/Cancer Genetics                                                                       3 cr.

The course serves as a theoretical introduction to the field of cancer genetics. To provide the attendants with sufficient experience to perform basic cytogenetic and molecular cytogenetic laboratory procedures and analyses of solid tumor material.

PHRM 723             Drug  Discovery and Development                                                                   1 cr.

This course outlines the fundamental concepts and processes of the modern molecular (structure) target-based drug discovery and development. The goal is to introduce the students to the steps necessary to translate bench side findings into bedside applications. The information to be presented in this course are will consider the recent progress in the academic research and pharmaceutical industry.

PHRM 725             Basic Concepts and Applications of                                                                  1 cr.

Biopharmaceuticals in Regenerative Medicine

This course provides the knowledge on the application of biopharmaceuticals in regenerative medicine and clarification of terms and definitions. Other topic that will be covered are general techniques to embed or attach biopharmaceuticals to carriers or their single application, effects of biopharmaceuticals on mammalian cells and whole organisms, adverse reactions of organism on carriers and biopharmaceuticals, selection of manipulation of cells and selected examples of biopharmaceutical application in regenerative medicine.

PHRM 726             Therapeutic  Applications  of Biotech Agents                                                  1 cr.

The course is designed to provide students with clinical and applied therapeutics of pharmacogenomics and pharmacology of biotech agents in various clinical conditions.

PHRM 727             Research Methodology                                                                                    1 cr.

This subject introduces postgraduate students to the various methodological approaches, both qualitative and quantitative, to health research. Students will gain an understanding of research design, implementation, and analysis and formulate their own research project.

PHRM 799              Thesis                                                                                                               9 cr.

Original research topics will be conducted by the students in the area of drug discoveries, molecular genetics as related to diseases, proteomics and microbial molecular biology. A thesis will be presented.